4a,5-Epoxy-17b-hydroxy-3-oxoandrostane-2a-carbonitrile
High-purity Trilostane active pharmaceutical ingredient manufactured under strict GMP conditions. Supplied as a white to off-white crystalline powder with comprehensive analytical documentation including Certificate of Analysis (COA)and regulatory compliance packages. Reliable supply chain for global veterinary pharmaceutical manufacturers.
A synthetic steroid analogue manufactured under GMP conditions with full traceability.
Trilostane is a synthetic steroid analogue that acts as a competitive inhibitor of 3b-hydroxysteroid dehydrogenase, an enzyme critical in the biosynthesis of cortisol and aldosterone. It belongs to the class of steroidogenesis inhibitors and features a distinctive epoxide and nitrile functional group.
Trilostane reversibly inhibits 3b-hydroxysteroid dehydrogenase (delta4-isomerase), blocking the conversion of pregnenolone to progesterone and subsequently reducing the synthesis of cortisol, aldosterone, and other corticosteroids in the adrenal cortex.
Each batch undergoes comprehensive analytical testing including HPLC assay, IR identification, related substances profiling, residual solvent analysis by GC, and granulometry. Full batch traceability guaranteed.
Full analytical results for batch 9040B2603001 against specification QS-9040B-1.
| Test Parameter | Method | Specification | Result |
|---|---|---|---|
|
AppearancePhysical description
|
Visual | White to off-white powder | Off-white powder |
|
IdentificationIR Spectroscopy
|
IR | IR spectrum of sample complies with Reference Standard | Conforms |
|
IdentificationHPLC Retention Time
|
HPLC | RT of the major peak complies with Reference Standard | Conforms |
|
Specific RotationOptical activity
|
Polarimetry | +135 to +142 deg (on dried basis) | +138 deg |
|
Loss on DryingMoisture content
|
Gravimetric | NMT 0.5% | 0.26% |
|
Residue on IgnitionInorganic residue
|
Ignition | NMT 0.1% | 0.07% |
|
Maximum Single ImpurityUnknown related substance
|
HPLC (%Area) | NMT 0.20% | 0.13% |
|
Total ImpuritiesSum of all related substances
|
HPLC (%Area) | NMT 1.0% | 0.27% |
|
AssayPotency
|
HPLC (%w/w) | 98.0% - 102.0% (on dried basis) | 99.5% |
|
Residual SolventsMethanol
|
GC (%w/w) | NMT 3000 ppm | 796 ppm |
|
GranularityParticle size distribution
|
Laser Diffraction | D[90] NMT 20 um | 11.033 um |
Trilostane API is primarily used in veterinary pharmaceutical formulations.
Trilostane is the active pharmaceutical ingredient in veterinary formulations used for the treatment of hyperadrenocorticism (Cushing's syndrome) in dogs. It is marketed under brand names such as Vetoryl and is the most widely prescribed medical treatment for canine Cushing's disease globally.
Utilized as a pharmacological tool in research settings studying adrenal steroidogenesis pathways, aldosterone biosynthesis disorders, and the development of novel steroidogenesis inhibitors. Also used in studies investigating Conn's syndrome and primary hyperaldosteronism.
Our fine-milled Trilostane powder (D[90] = 11 um) with controlled particle size distribution is optimized for capsule and oral dosage form manufacturing. The small particle size ensures consistent content uniformity and improved dissolution in finished formulations.
HDPE Double-Lined Drum
Standard packaging unit - Custom quantities availableAdd: Block 14, No.100, Luyun Road, Changsha 410205, Hunan, China.
Email: info@arshinevet.com
WeChat: +8618874001228
WhatsApp: +8615697311407
Tel：86-731-82294958
EN
ES
FR
AR