In modern, large-scale pig farms, the prevention and control of infectious diseases are paramount. Enrofloxacin, as a widely utilized veterinary antimicrobial agent, has demonstrated exceptional efficacy in treating both porcine diarrhea and respiratory ailments. Today, Arshine Lifescience invites you to delve into the pivotal role and significant efficacy of Enrofloxacin in veterinary applications. We are dedicated to supplying high-quality pharmaceutical raw materials globally, contributing to the advancement of animal husbandry health.

I. Role and Efficacy of Enrofloxacin in Veterinary Applications

Enrofloxacin, also known as ethyl ciprofloxacin or norfloxacin, typically appears as a slightly yellow or light yellow crystalline powder with a bitter taste. It is sparingly soluble in water and gradually turns orange-red upon exposure to light.

This broad-spectrum bactericidal drug exhibits potent killing effects, especially against mycoplasma, and demonstrates significant bactericidal action against bacteria such as Escherichia coli, Klebsiella pneumoniae, and Salmonella. As a veterinary antimicrobial drug, Enrofloxacin boasts excellent tissue distribution in animals, making it an ideal choice for highly effective antibacterial treatment.

Arshine Lifescience recognizes that post-weaning coughing and diarrhea are prevalent issues in piglets, often compounded by secondary infections and infectious pleuropneumonia. Enrofloxacin exerts a powerful bactericidal effect on these primary pathogens, enabling effective control of outbreaks and safeguarding piglet health.

The broad antibacterial spectrum of Enrofloxacin allows for the treatment of bacterial or mycoplasma infections affecting the respiratory, digestive, urinary, and reproductive systems, as well as skin and soft tissues in dogs and cats. In swine production, it effectively combats various diseases including streptococcal disease, edema disease, salmonellosis, mycoplasma pneumonia, and pleuropneumonia. Furthermore, for poultry, Enrofloxacin effectively addresses infections caused by Salmonella, Escherichia coli, Pasteurella multocida, and Haemophilus parasuis, making it a crucial component in poultry medication.

However, Arshine Lifescience advises that Enrofloxacin has poor palatability, rendering it unsuitable for oral administration to pigs via drinking water, which could lead to waste. Oral administration in pigs typically requires special processing or incorporation into feed to ensure accurate intake. To mitigate the development of bacterial resistance, prolonged single-drug use should be avoided. Alternating or combining Enrofloxacin with other drugs is recommended.

II. Combination Strategies and Precautions for Cephalosporin and Enrofloxacin

Combination Advantages: The combined use of Cephalosporin and Enrofloxacin has shown favorable results in treating exudative dermatitis in pigs. Typically, a 10% Enrofloxacin injection combined with a Cephalosporin for injection is administered intramuscularly once daily for 2-3 consecutive days, achieving a synergistic therapeutic effect.

Drug Interactions and Contraindications:

• Enrofloxacin can inhibit the metabolism of theophylline and caffeine, potentially leading to increased blood drug concentrations and toxic reactions. Caution is advised when co-administering these drugs.

• Antacids can reduce the gastrointestinal absorption of Enrofloxacin, diminishing its bioavailability; thus, concomitant use with antacids is not recommended.

• Mixing Enrofloxacin with strong acidic or alkaline liquids may cause precipitation.

• Chemical changes occur when Enrofloxacin is mixed with Gastric-protecting Fluid, resulting in turbidity; therefore, it should not be mixed for injection.

Dosage and Safety:

• Excessive doses of Enrofloxacin can lead to side effects.

• Enrofloxacin should not be used in pigs known to be sensitive to the drug.

• Prior to administering Enrofloxacin by intramuscular injection to a large group of young pigs, Arshine Lifescience recommends a trial dose for 1-2 pigs. After confirming no adverse reactions, large-scale administration should proceed with reasonable dosages.

In summary, Enrofloxacin is a broad-spectrum veterinary bactericidal agent recommended by Arshine Lifescience, effective against most bacteria, mycoplasmas, chlamydia, Eperythrozoon, and other pathogens, playing an indispensable role in maintaining animal health. Through the scientific and rational use of Enrofloxacin, we can more effectively control animal diseases and enhance farming efficiency—a core objective of the animal health solutions that Arshine Lifescience is committed to promoting.